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- Saint Seiya: The Hades
- Sakigake!! Otokojuku
- Sakura Taisen V: Episode 0 - Kouya no Samurai Musume
- Samurai Jack: The Shadow of Aku
- Samurai Shodown V
- Samurai Warriors
- Samurai Warriors 2
- Samurai Warriors 2 Empires
- Samurai Western
- Saturday Night Speedway
- Savage Skies
- Scaler
- Scarface: The World Is Yours
- Scarface: The World is Yours Collector's Edition
- Scooby Doo: Night Of 100 Frights
- SD Gundam Force: Showdown!
- Second Sight
- Secret Weapons Over Normandy
- Seek And Destroy
- Sega Bass Fishing Duel
- Sega Classics Collection
- SEGA Genesis Collection
- Sega Soccer Slam
- Sega Sports Tennis
- Sega SuperStars
- Sengoku Basara 2
- Sensible Soccer
- Serious Sam: Next Encounter
- Seven Samurai 20XX
- Shadow Hearts
- Shadow Hearts: Covenant
- Shadow Man: 2econd Coming
- Shadow Of Destiny
- Shadow of Rome
- Shadow of the Colossus
- Shadow the Hedgehog
- Shaman King: Master Spirits (import)
- Shaman King: Power of Spirit
- Shaun Palmer's Pro Snowboarder
- ShellShock: Nam '67
- Shin Megami Tensei: Devil Summoner: Raidou Kuzunoha vs. the Soulless Army
- Shin Megami Tensei: Digital Devil Saga 2
- Shin Megami Tensei: Nocturne
- Shin Megami Tensei: Persona 3
- Shining Force EXA
- Shining Tears
- Shinkon Gattai Godannar
- Shinobi
- Shinobido
- Showdown: Legends Of Wrestling
- Shox
- Shrek 2
- Shrek SuperSlam
- Shrek the Third
- Silent Hill 2
- Silent Hill 3
- Silent Hill 4: The Room
- Silent Line - Armored Core
- Silent Scope
- Silent Scope 2: Dark Silhouette
- Silent Scope 3
- Silpheed: The Lost Planet
- Siren
- Siren 2
- Sky Gunner
- Sky Odyssey
- Sled Storm
- Sly 2: Band of Thieves
- Sly 3: Honor Among Thieves
- Sly Cooper And The Thievius Raccoonus
- Smash Court Tennis Pro Tournament
- Smash Court Tennis Pro Tournament 2
- Smuggler's Run
- Smugglers Run 2 - Hostile Territory
- Sniper Elite
- SNK vs. Capcom: SVC Chaos
- Soccer America International Cup
- SOCOM 3: U.S. Navy SEALs
- SOCOM: U.S. Navy Seals II
- SOCOM: US Navy Seals
- Soldier of Fortune: Gold Edition
- Sonic Heroes
- Sonic Mega Collection Plus
- Sonic Riders
- Soul Reaver 2: Legacy of Kain
- Soulcalibur II
- Soulcalibur III
- Space Channel 5 Part 2
- Space Channel 5: Special Edition
- Spartan: Total Warrior
- Spawn: Armageddon
- Speed Kings
- sphinx and the cursed mummy
- Spider-man 2
- Spider-Man 3
- Spider-Man: Friend or Foe
- Spider-Man: The Movie
- Splashdown
- Splashdown: Rides Gone Wild
- SpongeBob SquarePants: Lights, Camera, Pants!
- SpongeBob SquarePants: Revenge of the Flying Dutchman
- SpongeBob SquarePants: The Battle For Bikini Bottom
- Spy Fiction
- Spy Hunter
- Spy vs. Spy
- SpyHunter 2
- Spyro: Enter The Dragonfly
- SSX
- SSX 3
- SSX on Tour
- SSX Tricky
- Star Ocean: Till the End of Time
- Star Trek Voyager Elite Force
- Star Trek: Encounters
- Star Trek: Shattered Universe
- Star Wars Episode III: Revenge of the Sith
- Star Wars Racer Revenge
- Star Wars: Battlefront
- Star Wars: Battlefront II
- Star Wars: Bounty Hunter
- Star Wars: Jedi Starfighter
- Star Wars: Starfighter
- Star Wars: Super Bombad Racing
- Star Wars: The Clone Wars
- Starsky & Hutch
- State Of Emergency
- State Of Emergency 2
- Steambot Chronicles
- Stolen
- Street Fighter Alpha Anthology
- Street Fighter Anniversary Collection
- Street Fighter EX 3
- Street Hoops
- Street Racing Syndicate
- Strike Force Bowling
- Stunt GP
- Stuntman
- Stuntman: Ignition
- Suikoden III
- Suikoden IV
- Summer Heat Beach Volleyball
- Summoner
- Sunny Garcia Surfing
- Super Bust-A-Move
- Super Bust-A-Move 2
- Super Dragon Ball Z
- Super Trucks Racing
- Supercar Street Challenge
- Superman Returns: The Videogame
- Superman: Shadow of Apokolips
- Surf's Up
- Surfing H3O
- SWAT: Global Strike Team
- Swing Away Golf
- Syphon Filter: The Omega Strain
